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03 December 2013 by Nieske Zabriskie in Skin  Newsletter 2013 December

A double-blind randomized controlled study published in August 2013 reports that supplementation with a mixture of soy isoflavones, lycopene, vitamin C, vitamin E and fish oil reduces wrinkles in post-menopausal women. According to the American Society of Plastic Surgeons, 14.6 million cosmetic plastic surgery procedures, including both minimally invasive and surgical, were performed in the United States in 2012, up five percent since 2011.

The researchers evaluated 160 post-menopausal women. The women received a high or low dose of a supplement drink containing soy isoflavones, lycopene, vitamin C and vitamin E plus a fish oil capsule or a placebo daily for 14 weeks. The investigators assessed the subjects for facial wrinkles and performed biopsies of the skin to assess collagen and elastin formation at the beginning of the study and again after the intervention period.

The researchers showed that supplementation with soy isoflavones, lycopene, vitamin C, vitamin E and fish oil can significantly reduce the depth of facial wrinkles. In addition, the investigators found that this improvement in facial wrinkles is associated with increased deposition of new collagen fibers in the dermis layer of the skin, located directly under the epidermis.

The investigators stated, “This study demonstrates that consumption of a mixture of soy isoflavones, lycopene, vitamin C, vitamin E and fish oil is able to induce a clinically measureable improvement in the depth of facial wrinkles following long term use. We have also shown, for the first time with an oral product, that the improvement is associated with increased deposition of new collagen fibers in the dermis.”