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Clinically proven to regenerate the skin’s upper layers by stimulating collagen production, thus thickening the epidermis. Palmitoyl Pentapeptide-3 is a synthetic protein that is a fragment of the C-terminal portion of collagen I (the most common type of the nineteen forms of collagen) combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. One could look at Palmitoyl Pentapeptide-3 as a man-made precursor to collagen I. When this protein is added to cultured human fibroblasts it enhances the synthesis of collagen I, collagen III and fibronectin. In vitro, Palmitoyl Pentapeptide-3 was found to stimulate collagen IV synthesis by 100-327% and to stimulate hyaluronic acid synthesis by 267%. In vivo Palmitoyl Pentapeptide-3 was found to stimulate collagen synthesis by 30-117%. Image analysis determined the effect Palmitoyl Pentapeptide-3 had on wrinkled skin. The six-month results are listed below, though significant results were seen in two months. Results: Mean wrinkle depth — Reduced 17% Surface area: deep wrinkles — Reduced 68% Surface area: moderate wrinkles — Reduced 51% Mean density of wrinkled area — Reduced 47% Skin roughness — Reduced 16% Main wrinkle volume — Reduced 24%. These results show that Palmitoyl Pentapeptide-3 had a dramatic effect on reducing the quantity and depth of wrinkles. It also improved surface smoothness.

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