Topical treatment with coenzyme Q10-containing formulas improves skin’s Q10 level and provides antioxidative effects.
Knott A1, Achterberg V1, Smuda C1, Mielke H1, Sperling G1, Dunckelmann K1, Vogelsang A1, Krüger A1, Schwengler H1, Behtash M1, Kristof S1, Diekmann H1, Eisenberg T1, Berroth A1, Hildebrand J1, Siegner R1, Winnefeld M1, Teuber F1, Fey S1, Möbius J1, Retzer D1, Burkhardt T1, Lüttke J1, Blatt T1.
Beiersdorf AG, Research & Development, Hamburg, Germany.
Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity.